Enthalpically driven peptide stabilization by protective osmolytes.
نویسندگان
چکیده
We determined the added enthalpic and entropic contributions of protective osmolytes to the folding of a model peptide into its native beta-hairpin state. In contrast to entropically driven steric "crowding", this study shows that sugars and polyols can act as protective osmolytes by primarily diminishing the unfavourable enthalpic contribution to folding.
منابع مشابه
Enthalpically driven peptide stabilization by protective osmolytesw
COMMUNICATION Daniel Harries et al. Enthalpically driven peptide stabilization by protective osmolytes FEATURE ARTICLE Liu-Zhu Gong et al. The role of double hydrogen bonds in asymmetric direct aldol reactions catalyzed by amino amide derivatives
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 35 شماره
صفحات -
تاریخ انتشار 2010